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Consider Primary Immunodeficiency – if

  • Recurrent infections or unusual or persistent infection
  • Life-threatening Infections
  • Blood cell counts low or persistently high

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TYPES of primary deficiency-

a) ANTIBODY PRODUCTION DEFECTS-

example

  • X-Linked Agammaglobulinemia
  • Common Variable Immunodeficiency (CVID)
  • X-Linked or Autosomal Hyper IgM Syndrome Hyper IgM
  • Selective IgA Deficiency
b) CELLULAR OR COMBINED DEFECTS
  • Severe Combined Immunodeficiency
  • Di- George Syndrome
  • Ataxia Telangiectasia
  • Wiskott-Aldrich Syndrome
c) PHAGOCYTIC CELL IMMUNE DEFECTS
  • Leukocyte Adhesion Defect
  • Chronic Granulomatous Disease
  • Chediak Higashi Syndrome
  • Cyclic Neutropenia
d) COMPLEMENT DEFECTS
  • C1 Esterase Inhibitor Deficiency
  • Complement Component Deficiencies

 

MANAGEMENT OF ANTIBODY PRODUCTION DEFECTS
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TREATMENT- Is by Immunoglobulin replacement

 

 

MANAGEMENT OF CELLULAR OR COMBINED DEFECTS

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MANAGEMENT OF PHAGOCYTIC CELL DEFECTS

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MANAGEMENT OF COMPLEMENT DEFECTS

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